KPV (Lys-Pro-Val) Research: PepT1-Mediated NF-kB Inhibition and Gut Epithelial Biology in Preclinical Models
KPV (Lys-Pro-Val) is the C-terminal tripeptide of alpha-MSH studied for anti-inflammatory activity in gut epithelial models. Unlike full-length alpha-MSH, KPV acts via PepT1 transport — not MC1R/cAMP — to inhibit NF-kB and MAP kinase at nanomolar concentrations. DSS colitis models show ~50% MPO reduction. Independent research compilation for scientific and educational reference only.
